hPCMA Photopolymerizable hydrogel is a human based, bioactive placenta-based platform that provides physiologically relevant microenvironments for cells culture. The precursor solution is easily prepared by reconstituting hPCMA lyophilizate in an aqueous solution with a photoinitiator. Afterwards, it can be cured upon light exposure to form a hydrogel with tuneable mechanical properties. hPCMA hydrogels provide great control over gelation time and matrix stiffness, enabling researchers to create the cell culture environment that better fits their needs.